Noble International Journal of Scientific Research

Online ISSN: 2521-0246 | Print ISSN: 2523-0573


    Volume 4 Number 1 January 2020


Pages: 01-10
Authors: Muhammad Kashif Javed*, Muhammad Ali, Javed Iqbal, Waseem Ahmed
Transition metal doped graphene is evaluated as drug delivery system for methotrexate (MTX) which belongs to anti-metabolic class of anticancer drugs. This study was carried out to evaluate therapeutic potentials of transition metal (TM) doped graphene as a drug delivery system for methotrexate (MTX) to treat cancer. To explore the effectiveness of TM doped graphene as a drug delivery system, its electronic, geometric and excited state properties were evaluated. The presence and nature of weak interaction forces between TM doped graphene and MTX were illustrated through non-covalent interaction (NCI) analysis. These forces are typically helpful for the easy drug offloading at the target. Frontier molecular orbital analysis exposed that charge was shifted from TM doped graphene to MTX through Co atoms present in TM doped graphene throughout excitation from HOMO to LUMO. Charge decomposition analysis (CDA) further supplemented the charge transfer from carrier to drug. It was shown that ?max for MTX-TM doped graphene complex was red shifted by 393 nm. The change in stabilization energies of natural bonding orbitals was observed through NBO analysis. The significant therapeutic potential of TM-doped graphene as a drug delivery system was confirmed during this study. And this study shall motivate the exploration of other 2D in drug delivery applications.

Aim & Scope Instructions for Authors Editorial Board Indexed/abstracted in Submit Manuscripts Archive

Call for Papers

Call for Quality PapersAuthors are invited to submit their quality and original research manuscripts/articles for possible publication in the following journals. Following journals are published by Noble Academic Publisher (NAP). Noble Internati...

Read More

Publication Ethics

NAP has certain standard of publication ethics to ensure the quality of publications and originality of contributions. We only consider those contributions that are unpublished, original and not copied right by othe...

Read More

Article Processing Charge

Article Processing Charges [APC]As with any other Open Access publishing company, with NAP there is no paper, no mailing, no subscriptions, and no restriction against using and sharing our journals. But we do have to pay for maintaining pub...

Read More